Siklos (hydroxycarbamide) is indicated in patients over 2 years of age with sickle cell anemia who experience recurrent moderate to severe painful crises.

Sickle cell anemia (SCA) is an inherited blood disorder related to hemoglobin that affects the shape and function of red blood cells, which are responsible for carrying oxygen throughout the body. Instead of being round and flexible, the red blood cells of people with SCA may become rigid, sticky, and crescent-shaped or sickle-shaped. These abnormally shaped cells can slow or block blood flow and cause a variety of symptoms and complications.

Sickle cell anemia (SCA) is diagnosed with a simple blood test called hemoglobin electrophoresis. This test detects the presence of abnormal hemoglobin, which causes sickle cell anemia. In many countries, newborns are routinely screened for SCA, allowing for early diagnosis and treatment, but older children and adults can also develop the disease. Early detection is crucial for managing symptoms and preventing complications.

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